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All animal procedures used in this study were in accordance with the National Institute of Health Guidelines for the Care and Use of Laboratory Animals [14]

An unresolved issue is whether GSH-mediated copper buffering primarily delays cuproptotic initiation or fundamentally determines the threshold for mitochondrial proteotoxic collapse

To test the effect of sustained repression of lipogenic programs and a concurrent sustained induction of NRF2 activity, we monitored mice for ten weeks following the induction of Gclc deletion alone (Gclc L-KO) or in combination with Nrf2 deletion (L-DKO) in the liver (Fig

Additionally, vitamin C protects the skin from damage caused by UV rays and environmental pollutants