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This finding could signal general clinician discomfort with medication approaches to ME/CFS

We need to have a realistic expectation that its not as effective as conventional medication like metformin for managing blood sugar

Baseline blood pressure level, degree of obesity, genetic predisposition, diet quality, and concurrent medications all influence whether someone will see meaningful reductions

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They are consistent with the known side effect profile of GLP-1 receptor agonists already approved in the UK (see, for example, the Wegovy Summary of Product Characteristics, available via the electronic Medicines Compendium)