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Citrate buffers, especially at higher concentrations (e.g., 23 mM), have been associated with increased pain, leading to a shift towards formulations with lower citrate content

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The applicant also noted that of the study's 62,965 eligible encounters, 1,473 (2.3 percent) used single-use cystoscopes and 61,492 (97.7 percent) used reusable cystoscopes

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If you've used a quality product consistently for 8 weeks with zero change, that's a reasonable point to check in with a healthcare professional