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They postulate the pain felt by patients is out of proportion to the damage seen, the pain is not just because cartilage over the bone gets worn down. They state the thin rim of the cartilage becomes inflamed and sends pain signals to the body

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Understanding the distinction between typical medication side effects and potential inflammatory conditions helps patients recognize warning signs requiring medical evaluation

Gene ontology categorization analysis indicated that many proteins involved in the electron transport and oxidation-reduction process were down-regulated in expression after riboflavin deficiency, including AOFB, DLD, NQO1, NDUFS1, AK1C2, AIFM1, SDHA, TRXR1, AK1C3, DERP12, MCAD, PLOD2, SRXN1, PLCA, NDUFV2, and ERO1A

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