glp-1 vs sglt2 weight loss Association between plausible genetic factors and from GLP1-RA and bariatric surgery Perspectives in weight control in

This metabolic adaptation is why weight loss plateaus

A 2025 case series published in PMC documented three patients on semaglutide or tirzepatide who prioritized muscle preservation through resistance training (3-5 days/week) and protein intake (1.6-2.3 g/kg/day relative to fat-free mass)

If you develop a firm raised area at a previous injection site, avoid that spot until it resolves and mention it to your prescriber at the next appointment

These effects have been attributed to improvements in insulin sensitivity, modulation of lipid metabolism, and activation of enteroendocrine and thermogenic gene programs

Tirzepatide is often our first recommendation for patients focused on maximizing results, while semaglutide is a great fit for those who want a gentler start or are working within a tighter budget