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We further explored the target genes in the transcriptome data and identified multiple genes that may serve as downstream targets of therapy for NASH

S3 show the results for the outcome MACE: both GLP-1RA and SGLT-2 inhibitors were associated with a lower risk for MACE (13% and 11%, respectively) as compared with placebo, and a lower risk for MACE as compared with DPP-4 inhibitors (12% and 11%, respectively)

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The biological objective is to shift efficacy away from Cmax-limited GLP-1 signaling toward exposure- and residence-timedriven pharmacology, while preserving controlled, functionally relevant GIP co-activation

Absolute contraindications to GLP-1 receptor agonists with the boxed warning include patients with a personal history of MTC, family history of MTC, or known MEN 2 syndrome