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It is well established that metabolic changes drive microglial polarization, and a number of pathways, including hypoxia-inducible factor-1alpha (HIF-1), forkhead box P3 (FOXP3), and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, have been implicated in facilitating these effects [73]

Diabetes 52 , 26152622 (2003)

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In the neuronal system, Nox-derived ROS are implicated in blood pressure regulation and hypertension, particularly in response to angiotensin II and aldosterone [75]