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10.1073/pnas.192399699 Proc Natl Acad Sci USA

The 2022 ACC guidelines recommend PCSK9 inhibitors and bempedoic acid based on a patients ASCVD risk and LDL cholesterol levels, particularly those with established CVD, high cardiovascular risk, or in patients who do not achieve LDL-C targets with maximally tolerated statin and ezetimibe therapy, or who are statin-intolerant [166]

In a 2025 randomized controlled trial published in JAMA Psychiatry , semaglutide significantly reduced weekly alcohol cravings compared with placebo, although reductions in overall alcohol consumption were less consistent

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Your doctor may need to adjust your medicine dosage to ensure safe use.