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4 Discussion The severe insulin resistance, hepatic steatosis, dyslipidaemia and hyperphagia that characterises lipodystrophy makes effective treatment challenging and limits the effectiveness of commonly used diabetes therapies (40, 41)

HFC, Hepatic Fat Content

Reference: Canapp SO, Farese JP, Schulz KS, et al

Imaging Phase contrast imaging was performed on a PrimoVert microscope (Zeiss) and images were acquired using ZEN software from Zeiss

However, multiple mechanisms have been suggested, including the following: i) Through degradation of different cellular components, autophagy allows for the turnover of resulting substrates for energy production and protein formation, which is considered essential for the preservation of cellular bioenergetics during AKI (Jiang et al., 2012)