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While several biotech companies are in the preclinical or early clinical trial phases of developing these microneedle patches, they are still years away from being reviewed by the FDA and available to the public

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Morgado-Carrasco et al., 2022): 3.1 Improper melanocytes activity and accumulation of melanocytes in the dermis and epidermis layers Although increase in melanin levels in melasma patients is a known fact, however, the exact mechanism of this increment is not fully understood

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