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A glucagon-like peptide-1 receptor agonist , or GLP-1, is a hormone in our body with numerous metabolic effects like stimulating the secretion of insulin, delaying gastric emptying, and increasing satiety by affecting the hypothalamus

Approximately 30% of patients with plaque psoriasis have type 2 diabetes, a rate 1.5 times higher than the general population (Armstrong et al., JAMA Dermatology , 2013)

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A 2021 comparative trial published in the Journal of Endocrinology found this combination produced 2.3 greater IGF-1 elevation than either compound alone at equivalent doses, with no increase in cortisol or prolactin spillover

Over-replacement is associated with symptoms of hyperthyroidism, including palpitations, weight loss, heat intolerance, and osteoporosis from long-term high doses