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Individual response to GLP-1 medications varies meaningfully variants in GLP1R (the GLP-1 receptor itself), GIPR (which matters specifically for tirzepatide's dual-agonist mechanism), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with different weight-loss curves and different tolerability profiles

however, the exact mechanism of action is unknown

doi: 10.2174/0929867321666140706130807

This peptide is used in laboratory research applications