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However, its relationship with arthroplasty timing remains complex, and available evidence does not yet define an optimal interval between bariatric surgery and joint replacement ( Other anti-obesity medications may also be considered according to efficacy, contraindications, tolerability, availability, and cost

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There may be confounders that cannot be identified with current knowledge

3 By contrast, oral semaglutide (Rybelsus) is a peptide that requires the absorption enhancer sodium N-(8-[2-hydroxybenzoyl]amino) caprylate (SNAC) to cross the gastrointestinal barrier and achieve bioavailability