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It enrolls approximately 10,000 participants with established cardiovascular disease, uses MACE as the primary endpoint, and is on a 3-4 year timeline
Genetic variants in the GLP1-related genes are linked to obesity and diabetes
The supplements dont appear to have elicited legal concern from GLP-1 drugmakers, but that could change if the products become competitors, said Claudia Lewis, co-chair of Venable LLPs FDA group
In practice, many obesity specialists have found themselves deviating from the label slowing down titration, adding intermediate doses, maintaining lower doses longer, or skipping weeks to help patients stay on therapy
Casson RJ, Wood JPM, Osborne NN
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