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However, in an editorial in Molecular Psychiatry, Substantial evidence has been accumulated that reveals metabolic defects in both the peripheral and central tissue of patients with SZ (see reviews by 31 P MRS) phospholipids and polyunsaturated fatty acids (PUFAs) were shown in SZ patients ( Moreover, there are several paradigmatic conditions such as Down syndrome, phenylketonuria, and various lipidoses ( CONCLUSION AND PERSPECTIVES During the purine catabolism, there are three major purine bases and their corresponding ribonucleosides, which consist of adenine/adenosine, G/Gr, and Hx/inosine ( Figure 2 )

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it must be supported by adequate theoretical characterization and biological evaluation for their safety