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Seek medical advice if you experience: Severe or persistent abdominal pain that does not go away Black, tarry, or bloody stools (a sign of potential GI bleeding) Vomiting blood or material that looks like coffee grounds A significant decrease in urination or swelling in your ankles/feet Signs of an allergic reaction, such as a rash, itching, or swelling Always disclose all medications, including supplements and over-the-counter pills, to your healthcare provider during your initial assessment and ongoing check-ins

Zhou YB, Sun HJ, Chen D, et al

Lancet 396 , 16751688 (2020)

Response to medication Your response to semaglutide will also be a factor in long-term use