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By facilitating GIP function at its full metabolic capacity alongside GLP-1, this interaction could effectively harness the full potential of incretin effect to enhance insulinotropic physiology and maintain euglycemia
Cardiovascular and Endothelial Benefits GLP-1 RAs have demonstrated robust cardiovascular protection in multiple large-scale trials, including LEADER, REWIND, and SUSTAIN-6, showing reduced rates of major adverse cardiac events independent of weight loss
The 3.5-point increase reflects stronger integration of GLP-1 therapy with structured nutritional interventions
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PLoS ONE 18(8 August):120 (2016) Liraglutide and cardiovascular outcomes in type 2 diabetes
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