Piezo1 removal in astrocytes reduced the hippocampal volume and overall brain mass, cutting the production of neurons, which affected cognition and mental function in the long term, while increased expression of Piezo1 significantly enhanced these functions [96]
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Amylins offering closest to market is CagriSema, which combines its successful GLP-1 receptor agonist semaglutide with cagrilintide, an amylin analogue
