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used trypsin digestion to show that only a central domain of a lysine-rich histone H1 from calf thymus (residues 37120) is in a folded conformation, whereas N- and C-terminal regions (residues 136 and 121213, respectively) are very accessible in chromatin and therefore likely not in a compact, folded conformation ( Grzelczak et al

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Homan KA, Gupta N, Kroll KT et al (2019) Flow-enhanced vascularization and maturation of kidney organoids in vitro