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Carlat Verdict: To prevent metabolic side effects when beginning an antipsychotic, start with metformin, but consider a GLP-1 RA for patients who have already been on antipsychotics for a while with a BMI 30 kg/m 2 (or 27 kg/m 2 and obesity-related health problems)

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These medications work through different biological pathways and do not interact in ways that cause serious contraindications

These non-selective effects create cardiovascular stress and uncomfortable side effects