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Amylin's primary physiological functions include [11] : Slowing gastric emptying: Delays the rate at which food enters the small intestine, reducing post-meal glucose spikes Controlling glucose metabolism: Reduces inappropriate hepatic glucose output during meals Promoting satiety: Acts on area postrema in the brainstem to reduce food intake In type 2 diabetes, amylin secretion is impaired alongside insulin deficiency, contributing to postprandial hyperglycemia and dysregulated satiety [12]

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10 The growing prevalence and burden of GI disorders highlight the urgent need for effective, safe, and sustainable treatment approaches

Although effective and safe treatments for obesity exist, weight loss medications are rarely prescribed for adults with obesity