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Collagen loss accelerates rapidly after menopause: women lose approximately 2% of collagen each year in the early postmenopausal period, totaling around 20% over five years

Yilmaz A , Reiss C , Weng A , et al

The choice between variants depends on goals: systemic anabolism favors IGF-1 LR3, while targeted local effects or minimizing systemic exposure favors IGF-1 DES

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Protect skin from environmental factors : Wear appropriate clothing in extreme temperatures, use sun protection (SPF 30 or higher), and avoid prolonged hot baths or showers, which can dry and irritate skin