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While the thought of an injection can be worrying, most patients find the procedure causes only mild, short-lived discomfort

Korean J Chem Eng 27:12461251

NeoCart, an autologous cartilage tissue implant, compared with microfracture for treatment of distal femoral cartilage lesions

Prolonged overdose of B6 (150-200 mg/day) over weeks can cause severe sensory-nervous-system dysfunction and ataxia.37 With normal usage serious adverse effects are not reported for pyridoxine (vitamin B6), however, diarrhoea, emesis and rosacea-like dermatitis may be observed in some cases (38)

The initial attempts to induce DE differentiation using small-molecule cocktails containing CHIR and IDE1 (CI-I and CI) proved inefficient