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To make an informed decision, patients and their parents or caregivers should be told that the risk of benign and malignant tumours in children with SPIGFD is lower than it is for healthy children without SPIGFD (because IGF-1 plays a role in the initiation and progression of benign and malignant tumours)

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[15] [37] [38] In August 2025, the Food and Drug Administration (FDA) expanded the indication for semaglutide (as Wegovy) to include the treatment of noncirrhotic metabolic-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH), with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) in adults

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After acidification with trifluoroacetic acid 1% (TFA) and centrifugation at 16,000 g for 5 min, resulting peptides were purified on StageTips according to Rappsilber et al