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In major depressive disorder (MDD) and other depression-like conditions, it is still hypothesized that serotonin concentration, which is abnormally reduced, is the main factor [93]

In cells with intact KEAP1-NRF2 system, transiently stabilized NRF2 induces transcriptional activation of genes encoding xCT, SLC7A11 , and two subunits of gamma-glutamylcysteine ligase (GCL), GCLC and GCLM , in response to oxidative and electrophilic stresses

Sources Jones DP, Sies H

3k), in part reflecting lower baseline values for these parameters in Gipr Syn/ mice

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