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77,83,84 In addition, the expression of ALDH1L2 is upregulated by some certain drugs, such as thapsigargin and tunicamycin, endoplasmic reticulum stress inducers in immortalized human B cells, 85 mitotane, an adjuvant monotherapy used for treating adrenocortical carcinoma, 86 and the indomethacin, an anti-inflammatory agent in breast cancer cells

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Unpublished studies in our laboratory have suggested that some amounts of MDM2, by inducing ubiquitination, are important for internalisation and activation of the IGF-1R