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Individuals with the syndrome show sudden gain in weight around their mid-torso, chest, abdomen, and face, often with thin legs and arms

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These studies indicate that the activation of STAT3 through different pathways of insulin/IGF-1 signaling is not only able to stimulate the expression of STAT3-dependent genes but it also affects the expression profiles of other genes, e.g., those activated by SMAD3 and FOXO factors