Semaglutide, the first dedicated GLP-1 obesity treatment, achieved 14.9% body weight reduction in the STEP 1 trial
On fatigue and bloating A two-month clinical trial of a three-strain probiotic on athletes found that daily supplementation led to significant improvements in self-rated markers of fatigue and bloating, attributed to the strains ability to strengthen gut barrier integrity, enhance microbial diversity, and increase short-chain fatty acid production.28 The three strains in question were Clostridium butyricum WB-STR-0006, Akkermansia muciniphila WB-STR-0001, and Bifidobacterium infantis , alongside 211mg of inulin
Retatrutide slows gastric emptying through GLP-1 receptor activation, allowing gut bacteria more time to ferment sulphur-containing foods such as eggs and cruciferous vegetables
It also promotes the growth of beneficial gut bacteria
However, our prior work has shown that many patients stop taking GLP-1 RAs prematurely