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Synthesis [edit] In the synthesis of melanotan II, an -amino group of lysine and an -carboxy group of aspartic acid have their orthogonal protection removed before undergoing a carbodiimide mediated lactamization, leading to an intermediate

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10.1371/journal.pgen.1000020 45 PfannenstielS.PraetoriusM.PlinkertP.BroughD.StaeckerH