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Evidence suggests that melatonin can act on circadian rhythms by directly influencing the activity of the SCN by both acute and clock-resetting mechanisms

If the therapy has been interrupted for a long time, the body is no longer adapted to the physiological changes caused by the medication

Even the 10 mg dose at 33.3 units requires estimating between markings

Serious, rare risks include pancreatitis and gallbladder disease, which is why strict medical supervision by a healthcare professional is non-negotiable