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Their findings showed that black garlic intake led to an increase in both total cholesterol and HDL-cholesterol levels, ultimately improving the total cholesterol/HDL-cholesterol ratio [73]

This occurs through the activation of adenylyl cyclase, leading to increased intracellular levels of cyclic AMP (cAMP)

These findings have stimulated clinical development attempts, particularly for NAD + modulators deemed suitable for human trials in terms of safety and upscaling, such as natural precursors