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The IRB scrutinizes how those risks are minimized and managed, often requiring elements such as stopping rules, independent safety monitoring, and clear plans for adverse event reporting

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Improved energy levels and better glycemic control become noticeable

the magnitude of HbA1c change in this non-diabetic population was modest, as would be expected Fasting insulin levels decreased, indicating improved insulin sensitivity Triglyceride and lipid profiles showed favourable changes, which may reduce cardiometabolic risk Waist circumference was substantially reduced, reflecting a decrease in visceral (abdominal) adiposity These findings are particularly relevant given that excess visceral fat is strongly associated with type 2 diabetes, cardiovascular disease, and metabolic syndrome

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