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Human relevance would require sufficient published, peer-reviewed controlled human studies, appropriate regulatory review, pharmacokinetic characterization, toxicology data, and long-term safety evaluation

14 The ROS and RNS can cause oxidative damage to DNA, lipids, carbohydrates and proteins, and thereby mediate an array of downstream processes that contribute to the development and progression of COPD

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Possible issues include mild initial irritation (especially at higher concentrations), breakouts in some users, and potential interference with other skincare ingredients