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There is a known metabolic defect in cardiometabolic disease this was highlighted most recently by Lefer et al., who showed that an impairment in the sulfurome is a hallmark feature of cardiometabolic disease

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Chronic Stress Stress triggers the production of chemicals like cortisol and others that damage cells through oxidation

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53

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