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462 In addition, the nucleotide-binding oligomeric domain 2 (NOD2) antagonist GSK669 has been shown to target GPVI, inhibit platelet adhesion to collagen, and reduce collagen-induced phosphorylation of Src, Syk, PLC2, and Akt

Endocrinology and metabolism clinics of North America

10.1523/JNEUROSCI.0345-16.2016 55

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If side effects are intolerable, the healthcare team can develop an appropriate management plan, which may include temporary dose reduction, additional symptomatic treatment, or transition to alternative diabetes medications