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Overall, 27,823 participants had exactly one SUD diagnosis (19.5%), 8,332 had two SUD diagnoses (5.9%), and 3,028 had three SUD diagnoses (2.1%)

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Corneal confocal microscopy is a promising new noninvasive diagnostic tool that provides objective quantification of small nerve fibers in the subbasal layer of the cornea, which holds the densest concentration of these fibers (Figure 2)

This unbreakable bond forms a cystine molecule that is difficult for the body to utilize as a precursor for intracellular glutathione production