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Clinical benefits of combining tirzepatide with vitamin B12 The weight loss results from tirzepatide with B12 mirror the SURMOUNT clinical trial outcomes

This aligns with prior research indicating that colorectal cancer exhibits a glycolytic phenotype, which could reduce its dependence on glutamine metabolism for antioxidant defense 35 and reflects the well-established metabolic heterogeneity of CRC, in which different subtypes rely on distinct metabolic programs

Pountos I, Georgouli T, Kontakis G, Giannoudis PV

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