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The emergence of GIP receptor (GIPR)GLP1 receptor (GLP1R) co-agonists has fostered growing interest in the actions of GIP and GLP1 in metabolically relevant tissues

In 2023, Eli Lilly entered the market with Zepbound (tirzepatide), boasting over 20% weight loss at 72 weeks and a slightly lower price

Ensuring adequate fluid intake (aim to drink plenty of fluids and keep your urine pale yellow, typically 6-8 glasses daily for most adults) supports normal bowel function and may help prevent both constipation and diarrhoea

In MS research, tolerogenic peptide approaches targeting myelin basic protein have shown early promise

PMID: 37253395 JCI Insight Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice