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However, a one-year randomized, double-blind, placebo-controlled trial in 253 elderly (65 years) adults with elevated homocysteine levels found that B vitamin supplementation (1,000 g/day of folate, 10 mg/day of vitamin B 6 , and 500 g/day of vitamin B 12 ) did not improve measures of cognitive function, including memory, despite lowering homocysteine levels (116)

Disruptions in PE metabolism can impair mitochondrial activity in the brain, contributing to depressive symptoms (Modica-Napolitano and Renshaw, 2004)

doi: 10.1016/S0140-6736(08)60725-4 62 CampbellKLiKYangFBraniganPEllosoMMBensonJet al

We found two MCODE enriched in the PPI network as shown in fig

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