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The Evidence-Based Metabolic Health Hierarchy Tier 1: Foundation (Non-Negotiable) Metabolic health starts with fundamentals that produce effects orders of magnitude larger than any supplement: Nutrition: Whole food emphasis, appropriate calorie balance for goals, adequate protein intake (1.6-2.2g/kg for active individuals), and high fiber consumption (25-38g daily) 33 Volpe, S.L

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The ability of proliferation decline shows in aged tendinous tissue with TSPCs aging [28]

In pharmaceuticals, they have been used to manage oxidative stress-related conditions including diabetes, cardiovascular disease, and neurodegenerative disorders (De Oliveira et al., 2025