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Side Effects and Tolerability: Comparing Both Medications Both semaglutide and tirzepatide share a common side effect profile rooted in their GLP-1 mechanism: nausea, vomiting, diarrhea, and constipation occur most frequently during the first 4-8 weeks as your body adapts

Furthermore, GLP-1 RAs seem to have similar safety profile in the IBD population to the one observed in the general population, based on real-world observations