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Combined targeted inhibition of mutated BRAF and downstream MEK kinases, or alternatively immune checkpoint inhibition, currently provide good therapeutic options for the systemic treatment of melanoma, offering a long-term survival to ~30% of the patients

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In AD pathology, if the protein is over-phosphorylated, it will separate from microtubules, leading to axonal microtubule disintegration (Wang and Mandelkow, 2016)

VV conceived the study, obtained funding, analyzed the data and drafted the manuscript