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Availability of data and materials The data set used during the current study are available from the corresponding author on reasonable request

Wang SS, Lin XZ, Tsai YT, Lee SD, Pan HB, Chou YH, Su CH, Lee CH, Shiesh SC, Lin CY et al (1988) Clinical significance of ultrasonography, computed tomography, and biochemical tests in the rapid diagnosis of gallstone-related pancreatitisa prospective study

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Studies of individual with both SNPs (C677T and A1298C) showed that subjects with heterozygosity for both mutations resulted in an even lower MTHFR activity than heterozygosity for single MTHFR mutations, while no subjects carry both homozygote for MTHFR mutations regardless which SNPs 15 Furthermore, There were studies of multiple polymorphisms of one-carbon metabolism and schizophrenia symptoms showed an increase negative symptoms severity with increase of risk alleles, suggesting a cumulative effects of risk SNPs in one-carbon metabolism 61