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Building upon ADAR2-associated RNA editing, one recent study developed AAVs that co-express the wild-type human ADAR2 catalytic domain fused to bacteriophage N peptide (Editase wt ) and Mecp2 -targeting guide RNAs [114]

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In addition, B12 deficiency-associated fatigue is often accompanied by other symptoms such as numbness and tingling, cognitive impairment (memory and concentration problems), mood swings (depression), skin changes (pale skin), shortness of breath, or fast heart rate