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Microdosing is not without controversy or risk

Adjustments to the medication dosage or timing may be necessary, or other interventions might be recommended to manage sleep disturbances

Another important form of NO-related posttranslational modification (PTM) is protein S-nitrosylation (SNO), a product of the interaction of NO with the sulfhydryl groups of cysteine which leads to the formation of S-nitrosothiols [147, 159]

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