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Phase 2 cagrilintide alone ~10.8% body weight reduction at 26 weeks (4.5mg) Phase 2 CagriSema combo ~15.6% body weight reduction at 32 weeks Phase 3 REDEFINE 1 ~22.7% body weight reduction at 68 weeks Phase 2 CagriSema combination trial The Phase 2 trial of CagriSema was published in The Lancet in 2023, and its results attracted immediate attention

High-intensity exercise within 2 to 4 hours of injection can worsen nausea, as both exercise and the medication reduce blood flow to the GI tract

Ek CJ, Habgood MD, Dennis R, Dziegielewska KM, Mallard C, Wheaton B, et al

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Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: Therapeutic implications