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When to Be Concerned While many period changes are normal during weight loss, there are times to check in with a provider: Youve missed three or more periods in a row Your bleeding is unusually heavy or painful You experience spotting for more than a few days between periods You think you might be pregnant You have a history of hormone imbalance or reproductive health issues Remember: GLP-1s are powerful, but theyre not one-size-fits-all

While each study may have its own unique requirements, most follow some general eligibility guidelines

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Because it is a compounded medication and not FDA-approved, many clinics now refer to both semaglutide and tirzepatide as peptides

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