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A 2023 analysis comparing GLP-1 drugs found that triple-receptor agonists like retatrutide produced greater reductions in caloric intake in the first two weeks compared to single or dual receptor drugs

Mol Neurobiol

Efficacy and safety of once-weekly tirzepatide for weight management compared to placebo: an updated systematic review and meta-analysis including the latest SURMOUNT-2 trial

The Slc12a8-encoded NMN-specific transporter has been recently demonstrated to be highly expressed in the small intestine [175], leading to the gradual understanding of the pharmacokinetics of NMN [42,167]

While weight loss might lead to reduced health care costs (estimates suggest a reduction of around $250 billion), the current prices of the medications mean that the math doesnt quite add up for insurance companies