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These data support the rationale that tumors with elevated GST expression are more sensitive to the cytotoxic effects of TLK286

Warning signs requiring urgent evaluation include persistent vomiting that prevents fluid intake, severe upper abdominal pain (particularly if radiating to the back), signs of hypoglycemia that don't resolve with carbohydrate intake, symptoms of dehydration (decreased urination, extreme thirst, dizziness), or any other concerning reactions

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PlexusDx providers can coordinate care with obstetric and pediatric teams to support safe resumption of therapy when nursing is complete or when individual circumstances permit