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While alpha-MSH is more potent, KPV's lack of side effects and ease of administration make it a subject of research interest

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They are environmental factors, diet, genetic defects, stress and drugs

Although glutamate is the major downstream product of glutamine, glutamate supplementation during glutamine deprivation cannot rescue the impaired cell growth or mitochondrial respiration 16,43,44,45 , indicating that mitochondrial GLS-catalyzed cleavage of the gamma-nitrogen of glutamine is essential for glutaminolysis